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Distinct contributions of Aire and antigen presenting cell subsets to the generation of self-tolerance in the thymus
The contribution of thymic antigen presenting cell (APC) subsets in selecting a selftolerant T cell population remains unclear. We show that bone marrow (BM) APCs and medullary thymic epithelial cells (mTECs) played non-overlapping roles in shaping the T cell receptor (TCR) repertoire by deletion an...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175925/ https://ncbi.nlm.nih.gov/pubmed/25220213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.08.007 |
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