Distinct contributions of Aire and antigen presenting cell subsets to the generation of self-tolerance in the thymus

The contribution of thymic antigen presenting cell (APC) subsets in selecting a selftolerant T cell population remains unclear. We show that bone marrow (BM) APCs and medullary thymic epithelial cells (mTECs) played non-overlapping roles in shaping the T cell receptor (TCR) repertoire by deletion an...

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Bibliografiske detaljer
Main Authors: Perry, Justin S. A., Lio, Chan-Wang J., Kau, Andrew L., Nutsch, Katherine, Yang, Zhuo, Gordon, Jeffrey I., Murphy, Kenneth M., Hsieh, Chyi-Song
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175925/
https://ncbi.nlm.nih.gov/pubmed/25220213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.08.007
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