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Cloning, purification, crystallization and preliminary crystallographic analysis of the human histone deacetylase sirtuin 1
Human sirtuin 1 is a member of the histone deacetylase family and is involved in cellular aging, tumourigenesis and cellular metabolism. Recombinant sirtuin 1 comprising residues 140–747 was crystallized using the hanging-drop vapour-diffusion method. The crystal diffracted to 3.4 Å resolution and b...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
International Union of Crystallography
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080150/ https://ncbi.nlm.nih.gov/pubmed/21505241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111003277 |
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