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Conformationally Homogeneous Heterocyclic Pseudo-Tetrapeptides as Three-Dimensional Scaffolds for Rational Drug Design: Mapping the Structural Basis Set and Application to the Design of Receptor-Selective Somatostatin Analogues

Many protein-protein interactions are mediated through the recognition of β-turn secondary structures. Consequently, small-molecule β-turn mimetics are invaluable as probes for assessing bioactive ligand conformations, establishing pharmacophoric requirements, and pursuing rational drug design. Whil...

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Main Authors: Beierle, John M., Horne, W. Seth, van Maarseveen, Jan H., Waser, Beatrice, Reubi, Jean Claude, Reza Ghadiri, M.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080139/
https://ncbi.nlm.nih.gov/pubmed/19266506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200805901
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