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Conformationally Homogeneous Heterocyclic Pseudo-Tetrapeptides as Three-Dimensional Scaffolds for Rational Drug Design: Mapping the Structural Basis Set and Application to the Design of Receptor-Selective Somatostatin Analogues
Many protein-protein interactions are mediated through the recognition of β-turn secondary structures. Consequently, small-molecule β-turn mimetics are invaluable as probes for assessing bioactive ligand conformations, establishing pharmacophoric requirements, and pursuing rational drug design. Whil...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3080139/ https://ncbi.nlm.nih.gov/pubmed/19266506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200805901 |
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