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Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels
The human ether-a-go-go-related gene (hERG) channel, a member of a family of voltage-gated potassium (K(+)) channels, plays a critical role in the repolarization of the cardiac action potential. The reduction of hERG channel activity as a result of adverse drug effects or genetic mutations may cause...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079779/ https://ncbi.nlm.nih.gov/pubmed/21362439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.02.016 |
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