Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

The human ether-a-go-go-related gene (hERG) channel, a member of a family of voltage-gated potassium (K(+)) channels, plays a critical role in the repolarization of the cardiac action potential. The reduction of hERG channel activity as a result of adverse drug effects or genetic mutations may cause...

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Main Authors: Xia, Menghang, Shahane, Sampada, Huang, Ruili, Titus, Steven A., Shum, Enoch, Zhao, Yong, Southall, Noel, Zheng, Wei, Witt, Kristine L., Tice, Raymond R., Austin, Christopher P.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079779/
https://ncbi.nlm.nih.gov/pubmed/21362439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.02.016
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