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Repetitive Nerve Stimulation Transiently Opens the Mitochondrial Permeability Transition Pore in Motor Nerve Terminals of Symptomatic Mutant SOD1 Mice
Mitochondria in motor nerve terminals temporarily sequester large Ca(2+) loads during repetitive stimulation. In wild-type mice this Ca(2+) uptake produces a small (<5 mV), transient depolarization of the mitochondrial membrane potential (Ψ(m), motor nerve stimulated with at 100 Hz for 5 s). We d...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3079773/ https://ncbi.nlm.nih.gov/pubmed/21310237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.01.031 |
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