Overexpression of Cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

We reported previously that mice overexpressing Cyp7a1 (Cyp7a1-tg) are protected against high fat diet-induced hypercholesterolemia, obesity and insulin resistance (1). Here we investigated the underlying mechanism of bile acid signaling in maintaining cholesterol homeostasis in Cyp7a1-tg mice. Cyp7...

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Hauptverfasser: Li, Tiangang, Matozel, Michelle, Boehme, Shannon, Kong, Bo, Nilsson, Lisa-Mari, Guo, Grace, Ellis, Ewa, Chiang, John Y. L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3079544/
https://ncbi.nlm.nih.gov/pubmed/21319191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24107
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