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Bile acids and cytokines inhibit the human cholesterol 7α-hydroxylase gene via the JNK/c-Jun pathway

Cholesterol 7α-hydroxylase (CYP7A1) of the bile acid biosynthesis pathway is suppressed by bile acids and inflammatory cytokines. Bile acids are known to induce inflammatory cytokines to activate the MAPK/JNK signaling pathway that inhibits CYP7A1 gene transcription. c-Jun has been postulated to med...

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Bibliografiske detaljer
Main Authors: Li, Tiangang, Jahan, Asmeen, Chiang, John Y.L.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526464/
https://ncbi.nlm.nih.gov/pubmed/16729332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.21183
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