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DNA looping by the HMG-box domains of HMG1 and modulation of DNA binding by the acidic C-terminal domain.

We have compared HMG1 with the product of tryptic removal of its acidic C-terminal domain termed HMG3, which contains two 'HMG-box' DNA-binding domains. (i) HMG3 has a higher affinity for DNA than HMG1. (ii) Both HMG1 and HMG3 supercoil circular DNA in the presence of topoisomerase I. Supe...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Stros, M, Stokrová, J, Thomas, J O
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 1994
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307928/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8152909/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.6.1044
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