DNA looping by the HMG-box domains of HMG1 and modulation of DNA binding by the acidic C-terminal domain.
We have compared HMG1 with the product of tryptic removal of its acidic C-terminal domain termed HMG3, which contains two 'HMG-box' DNA-binding domains. (i) HMG3 has a higher affinity for DNA than HMG1. (ii) Both HMG1 and HMG3 supercoil circular DNA in the presence of topoisomerase I. Supercoiling b...
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| Veröffentlicht in: | Nucleic Acids Res |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1994
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307928/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8152909/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.6.1044 |
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