TERRA and hnRNPA1 Orchestrate an RPA-to-POT1 Switch on Telomeric Single-Stranded DNA

Maintenance of telomeres requires both DNA replication and telomere ‘capping’ by shelterin. These two processes employ two single-stranded DNA (ssDNA)-binding proteins, replication protein A (RPA) and protection of telomeres 1 (POT1). Although RPA and POT1 each have a critical role at telomeres, how...

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Bibliografiske detaljer
Main Authors: Flynn, Rachel Litman, Centore, Richard C., O’Sullivan, Roderick J., Rai, Rekha, Tse, Alice, Songyang, Zhou, Chang, Sandy, Karlseder, Jan, Zou, Lee
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078637/
https://ncbi.nlm.nih.gov/pubmed/21399625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09772
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