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Toll-Like Receptor 3-Specific dsRNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-presentation, CTL Responses and Antiviral Protection
Maturation of dendritic cells (DC) to competent APC is essential for the generation of acquired immunity and is a major function of adjuvants. dsRNA, a molecular signature of viral infection, drives DC maturation by activating TLR3, but the size of dsRNA required to activated DC and the expression p...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3078629/ https://ncbi.nlm.nih.gov/pubmed/21242525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002845 |
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