Toll-Like Receptor 3-Specific dsRNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-presentation, CTL Responses and Antiviral Protection

Maturation of dendritic cells (DC) to competent APC is essential for the generation of acquired immunity and is a major function of adjuvants. dsRNA, a molecular signature of viral infection, drives DC maturation by activating TLR3, but the size of dsRNA required to activated DC and the expression p...

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Hlavní autoři: Jelinek, Ivett, Leonard, Joshua N., Price, Graeme, Brown, Kevin N., Meyer-Manlapat, Anna, Goldsmith, Paul K., Wang, Yan, Venzon, David, Epstein, Suzanne L., Segal, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078629/
https://ncbi.nlm.nih.gov/pubmed/21242525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002845
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