Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing

Methylation on lysine 9 of histone H3 (H3K9me) and DNA methylation play important roles in the transcriptional silencing of specific genes and repetitive elements. Both marks are detected on class I and II endogenous retroviruses (ERVs) in murine embryonic stem cells (mESCs). Recently, we reported t...

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Detalhes bibliográficos
Main Authors: Leung, Danny C., Dong, Kevin B., Maksakova, Irina A., Goyal, Preeti, Appanah, Ruth, Lee, Sandra, Tachibana, Makoto, Shinkai, Yoichi, Lehnertz, Bernhard, Mager, Dixie L., Rossi, Fabio, Lorincz, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078371/
https://ncbi.nlm.nih.gov/pubmed/21427230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014660108
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