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Unsuspected pathway of the allosteric transition in hemoglobin

Large conformational transitions play an essential role in the function of many proteins, but experiments do not provide the atomic details of the path followed in going from one end structure to the other. For the hemoglobin tetramer, the transition path between the unliganded (T) and tetraoxygenat...

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Detalhes bibliográficos
Main Authors: Fischer, Stefan, Olsen, Kenneth W., Nam, Kwangho, Karplus, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078355/
https://ncbi.nlm.nih.gov/pubmed/21415366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011995108
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