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Trapping the ATP binding state leads to a detailed understanding of the F(1)-ATPase mechanism

The rotary motor enzyme F(o)F(1)-ATP synthase uses the proton-motive force across a membrane to synthesize ATP from ADP and P(i) (H(2)PO(4)(−)) under cellular conditions that favor the hydrolysis reaction by a factor of 2 × 10(5). This remarkable ability to drive a reaction away from equilibrium by...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Nam, Kwangho, Pu, Jingzhi, Karplus, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273398/
https://ncbi.nlm.nih.gov/pubmed/25453082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419486111
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