Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

The CATERPILLER (CLR/NLR) gene family encodes a family of putative nucleotide-binding proteins important for host defense. Although nucleotide binding is thought to be central to this family, this aspect is largely unstudied. The CATERPILLER protein cryopyrin/NALP3 regulates IL-1β processing by asse...

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Bibliografiske detaljer
Main Authors: Duncan, Joseph A., Bergstralh, Daniel T., Wang, Yanhong, Willingham, Stephen B., Ye, Zhengmao, Zimmermann, Albert G., Ting, Jenny Pan-Yun
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2007
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876568/
https://ncbi.nlm.nih.gov/pubmed/17483456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611496104
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