Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

BACKGROUND: Micronuclei (MN) in mammalian cells serve as a reliable biomarker of genomic instability and genotoxic exposure. Elevation of MN is commonly observed in cells bearing intrinsic genomic instability and in normal cells exposed to genotoxic agents. DNA double-strand breaks are marked by pho...

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Main Authors: Xu, Bing, Sun, Zhaoliang, Liu, Zhaojian, Guo, Haiyang, Liu, Qiao, Jiang, Haiyan, Zou, Yongxin, Gong, Yaoqin, Tischfield, Jay A., Shao, Changshun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078113/
https://ncbi.nlm.nih.gov/pubmed/21525980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018618
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