लोड हो रहा है...
Transcription factor T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the RORγt gene
Overactive T(H)17 responses are tightly linked to the development of autoimmunity, yet the factors that negatively regulate differentiation of this lineage remain unknown. Here, we report that T-bet suppresses the development of the T(H)17 cell lineage by inhibiting the transcription of Rorc. T-bet...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077962/ https://ncbi.nlm.nih.gov/pubmed/21151104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1969 |
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