Transcription factor T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the RORγt gene

Overactive T(H)17 responses are tightly linked to the development of autoimmunity, yet the factors that negatively regulate differentiation of this lineage remain unknown. Here, we report that T-bet suppresses the development of the T(H)17 cell lineage by inhibiting the transcription of Rorc. T-bet...

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Main Authors: Lazarevic, Vanja, Chen, Xi, Shim, Jae-Hyuck, Hwang, Eun-Sook, Jang, Eunjung, Bolm, Alexandra N., Oukka, Mohamed, Kuchroo, Vijay K., Glimcher, Laurie H.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077962/
https://ncbi.nlm.nih.gov/pubmed/21151104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1969
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