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Molecular biology and pathology of prion strains in sporadic human prion diseases

Prion diseases are believed to propagate by the mechanism involving self-perpetuating conformational conversion of the normal form of the prion protein, PrP(C), to the misfolded, pathogenic state, PrP(Sc). One of the most intriguing aspects of these disorders is the phenomenon of prion strains. It i...

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Bibliografische gegevens
Hoofdauteurs: Gambetti, Pierluigi, Cali, Ignazio, Notari, Silvio, Kong, Qingzhong, Zou, Wen-Quan, Surewicz, Witold K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077936/
https://ncbi.nlm.nih.gov/pubmed/21058033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-010-0761-3
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