The Effect of Formaldehyde Fixation on RNA: Optimization of Formaldehyde Adduct Removal

Formalin-fixed, paraffin-embedded tissues generally provide low yields of extractable RNA that exhibit both covalent modification of nucleic acid bases and strand cleavage. This frustrates efforts to perform retrospective analyses of gene expression using archival tissue specimens. A variety of cond...

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Bibliografiske detaljer
Main Authors: Evers, David L., Fowler, Carol B., Cunningham, Brady R., Mason, Jeffrey T., O'Leary, Timothy J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2011
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077733/
https://ncbi.nlm.nih.gov/pubmed/21497290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2011.01.010
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