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The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers
Integrins containing the β(3) subunit are key players in tumor growth and metastasis. A functional Leu33Pro polymorphism (rs5918) in the β(3) subunit of the integrin gene (ITGB3) has previously been suggested to act as a modifier of ovarian cancer risk in Polish BRCA1 mutation carriers. To investiga...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077711/ https://ncbi.nlm.nih.gov/pubmed/19876733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-009-0595-7 |
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