Nephrocystin-4 Regulates Pyk2-induced Tyrosine Phosphorylation of Nephrocystin-1 to Control Targeting to Monocilia

Nephronophthisis is the most common genetic cause of end-stage renal failure during childhood and adolescence. Genetic studies have identified disease-causing mutations in at least 11 different genes (NPHP1–11), but the function of the corresponding nephrocystin proteins remains poorly understood. T...

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Autors principals: Liebau, Max C., Höpker, Katja, Müller, Roman U., Schmedding, Ingolf, Zank, Sibylle, Schairer, Benjamin, Fabretti, Francesca, Höhne, Martin, Bartram, Malte P., Dafinger, Claudia, Hackl, Matthias, Burst, Volker, Habbig, Sandra, Zentgraf, Hanswalter, Blaukat, Andree, Walz, Gerd, Benzing, Thomas, Schermer, Bernhard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077625/
https://ncbi.nlm.nih.gov/pubmed/21357692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165464
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