The Ciliary Protein Nephrocystin-4 Translocates the Canonical Wnt Regulator Jade-1 to the Nucleus to Negatively Regulate β-Catenin Signaling

Nephronophthisis (NPH) is an autosomal-recessive cystic kidney disease and represents the most common genetic cause for end-stage renal disease in children and adolescents. It can be caused by the mutation of genes encoding for the nephrocystin proteins (NPHPs). All NPHPs localize to primary cilia,...

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Detalhes bibliográficos
Main Authors: Borgal, Lori, Habbig, Sandra, Hatzold, Julia, Liebau, Max C., Dafinger, Claudia, Sacarea, Ilinca, Hammerschmidt, Matthias, Benzing, Thomas, Schermer, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408186/
https://ncbi.nlm.nih.gov/pubmed/22654112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.385658
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