DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell death. Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced in the RPE of humans with GA, and that conditional ablation of Dicer1, but...

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Detalhes bibliográficos
Main Authors: Kaneko, Hiroki, Dridi, Sami, Tarallo, Valeria, Gelfand, Bradley D., Fowler, Benjamin J., Cho, Won Gil, Kleinman, Mark E., Ponicsan, Steven L., Hauswirth, William W., Chiodo, Vince A., Karikó, Katalin, Yoo, Jae Wook, Lee, Dong-ki, Hadziahmetovic, Majda, Song, Ying, Misra, Smita, Chaudhuri, Gautam, Buaas, Frank W., Braun, Robert E., Hinton, David R., Zhang, Qing, Grossniklaus, Hans E., Provis, Jan M., Madigan, Michele C., Milam, Ann H., Justice, Nikki L., Albuquerque, Romulo J.C., Blandford, Alexander D., Bogdanovich, Sasha, Hirano, Yoshio, Witta, Jassir, Fuchs, Elaine, Littman, Dan R., Ambati, Balamurali K., Rudin, Charles M., Chong, Mark M.W., Provost, Patrick, Kugel, Jennifer F., Goodrich, James A., Dunaief, Joshua L., Baffi, Judit Z., Ambati, Jayakrishna
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077055/
https://ncbi.nlm.nih.gov/pubmed/21297615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09830
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