Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A

VEGF-A promotes angiogenesis in many tissues. Here we report that choroidal neovascularization (CNV) incited by injury was increased by excess VEGF-A before injury but was suppressed by VEGF-A after injury. This unorthodox antiangiogenic effect was mediated via VEGFR-1 activation and VEGFR-2 deactiv...

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Autores principales: Nozaki, Miho, Sakurai, Eiji, Raisler, Brian J., Baffi, Judit Z., Witta, Jassir, Ogura, Yuichiro, Brekken, Rolf A., Sage, E. Helene, Ambati, Balamurali K., Ambati, Jayakrishna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1359054/
https://ncbi.nlm.nih.gov/pubmed/16453023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26316
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