Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes

Invariant natural killer T cells (iNKT cells) are innate-like T cells important in immune regulation, antimicrobial protection, and anti-tumor responses. They express semi-invariant T cell receptors, which recognize glycolipid antigens. Their positive selection is mediated by double-positive (DP) th...

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Bibliografiska uppgifter
Huvudupphovsmän: Albu, Diana I., VanValkenburgh, Jeffrey, Morin, Nicole, Califano, Danielle, Jenkins, Nancy A., Copeland, Neal G., Liu, Pentao, Avram, Dorina
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2011
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076841/
https://ncbi.nlm.nih.gov/pubmed/21444811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014304108
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