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BCL11B is required for positive selection and survival of double-positive thymocytes
Transcriptional control of gene expression in double-positive (DP) thymocytes remains poorly understood. We show that the transcription factor BCL11B plays a critical role in DP thymocytes by controlling positive selection of both CD4 and CD8 lineages. BCL11B-deficient DP thymocytes rearrange T cell...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118514/ https://ncbi.nlm.nih.gov/pubmed/17998389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070863 |
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