Antigen-specific clonal expansion and cytolytic effector function of CD8(+) T lymphocytes depend on the transcription factor Bcl11b

CD8(+) T lymphocytes mediate the immune response to viruses, intracellular bacteria, protozoan parasites, and tumors. We provide evidence that the transcription factor Bcl11b/Ctip2 controls hallmark features of CD8(+) T cell immunity, specifically antigen (Ag)-dependent clonal expansion and cytolyti...

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Bibliografiske detaljer
Main Authors: Zhang, Shuning, Rozell, Mike, Verma, Raj K., Albu, Diana I., Califano, Danielle, VanValkenburgh, Jeffrey, Merchant, Akeel, Rangel-Moreno, Javier, Randall, Troy D., Jenkins, Nancy A., Copeland, Neal G., Liu, Pentao, Avram, Dorina
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916134/
https://ncbi.nlm.nih.gov/pubmed/20660613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092136
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