IL-15 transpresentation promotes both human T-cell reconstitution and T-cell–dependent antibody responses in vivo

Cytokine immunotherapies targeting T lymphocytes are attractive clinical interventions against viruses and tumors. In the mouse, the homeostasis of memory α/β CD8(+) T cells and natural killer (NK) cells is significantly improved with increased IL-15 bioavailability. In contrast, the role of “transp...

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Bibliografiske detaljer
Main Authors: Huntington, Nicholas D., Alves, Nuno L., Legrand, Nicolas, Lim, Annick, Strick-Marchand, Helene, Mention, Jean-Jacques, Plet, Ariane, Weijer, Kees, Jacques, Yannick, Becker, Pablo D., Guzman, Carlos, Soussan, Patrick, Kremsdorf, Dina, Spits, Hergen, Di Santo, James P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076818/
https://ncbi.nlm.nih.gov/pubmed/21444793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019167108
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