Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

The homeostatic control mechanisms regulating human leukocyte numbers are poorly understood. Here, we assessed the role of phagocytes in this process using human immune system (HIS) BALB/c Rag2(−/−)IL-2Rγc(−/−) mice in which human leukocytes are generated from transplanted hematopoietic progenitor c...

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Detalhes bibliográficos
Main Authors: Legrand, Nicolas, Huntington, Nicholas D., Nagasawa, Maho, Bakker, Arjen Q., Schotte, Remko, Strick-Marchand, Hélène, de Geus, Sandra J., Pouw, Stephan M., Böhne, Martino, Voordouw, Arie, Weijer, Kees, Di Santo, James P., Spits, Hergen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156191/
https://ncbi.nlm.nih.gov/pubmed/21788504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101398108
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