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Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway

PURPOSE: Our previous studies have shown that benzyl isothiocyante (BITC) suppresses pancreatic cancer growth by inducing apoptosis but the molecular mechanism was unclear. In the present study we hypothesized the involvement of PI3K/AKT/FOXO pathway in BITC induced apoptosis. EXPERIMENTAL DESIGN: M...

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Bibliografiske detaljer
Main Authors: Boreddy, Srinivas Reddy, Pramanik, Kartick C., Srivastava, Sanjay K.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076680/
https://ncbi.nlm.nih.gov/pubmed/21350002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1891
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