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Benzyl Isothiocyanate Suppresses Pancreatic Tumor Angiogenesis and Invasion by Inhibiting HIF-α/VEGF/Rho-GTPases: Pivotal Role of STAT-3

Our previous studies have shown that benzyl isothiocyanate (BITC) suppresses pancreatic tumor growth by inhibiting STAT-3; however, the exact mechanism of tumor growth suppression was not clear. Here we evaluated the effects and mechanism of BITC on pancreatic tumor angiogenesis. Our results reveal...

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Detalhes bibliográficos
Main Authors: Boreddy, Srinivas Reddy, Sahu, Ravi P., Srivastava, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189946/
https://ncbi.nlm.nih.gov/pubmed/22016776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025799
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