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Benzyl isothiocyanate mediated inhibition of histone deacetylase leads to NF-κB turn-off in human pancreatic carcinoma cells

NF-κB/p65 is constitutively activated in pancreatic cancers where it plays critical role in the transcriptional activation of multiple cell survival genes. We have previously demonstrated the apoptosis-inducing effects of BITC in pancreatic cancer cells. We hypothesized that inhibition of NF-κB/p65...

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Detalhes bibliográficos
Main Authors: Batra, Sanjay, Sahu, Ravi P., Kandala, Prabodh K., Srivastava, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946330/
https://ncbi.nlm.nih.gov/pubmed/20484017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1146
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