RNA interference-mediated knockdown of p21(WAF1) enhances anti-tumor cell activity of oncolytic adenoviruses

The ability of oncolytic adenoviruses to replicate in and lyse cancer cells offers a potential therapeutic approach. However, selectivity and efficacy of adenovirus replication need to be improved. In this study, we present that loss of p21(WAF1) promotes adenovirus replication and more effective ce...

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Библиографические подробности
Главные авторы: Shiina, M, Lacher, M D, Christian, C, Korn, W M
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2009
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076587/
https://ncbi.nlm.nih.gov/pubmed/19407849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2009.29
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