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A Dynamical Systems Model for Combinatorial Cancer Therapy Enhances Oncolytic Adenovirus Efficacy by MEK-Inhibition

Oncolytic adenoviruses, such as ONYX-015, have been tested in clinical trials for currently untreatable tumors, but have yet to demonstrate adequate therapeutic efficacy. The extent to which viruses infect targeted cells determines the efficacy of this approach but many tumors down-regulate the Coxs...

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Detalhes bibliográficos
Main Authors: Bagheri, Neda, Shiina, Marisa, Lauffenburger, Douglas A., Korn, W. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040662/
https://ncbi.nlm.nih.gov/pubmed/21379332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001085
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