Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

Syndrome X, typified by obesity, insulin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic thiazolidinediones (TZDs). Peroxisome proliferator-activated receptor (PPAR) γ, a target of TZDs, is expressed abundantly in adipocytes, suggesting an important ro...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: He, Weimin, Barak, Yaacov, Hevener, Andrea, Olson, Peter, Liao, Debbie, Le, Jamie, Nelson, Michael, Ong, Estelita, Olefsky, Jerrold M., Evans, Ronald M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307633/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14660788/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2536828100
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