Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy

The hyperglycemia of maternal diabetes suppresses the glucose transporter-1 (GLUT1) facilitative glucose transporter 49–66% in preimplantation embryos. Glucose uptake is reduced and apoptosis is activated. We hypothesized that the reduction of embryonic GLUT1 may play a key role in the malformations...

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Main Authors: Heilig, Charles W., Saunders, Thomas, Brosius, Frank C., Moley, Kelle, Heilig, Kathleen, Baggs, Raymond, Guo, LiRong, Conner, David
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC307616/
https://ncbi.nlm.nih.gov/pubmed/14673082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536196100
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