Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy

The hyperglycemia of maternal diabetes suppresses the glucose transporter-1 (GLUT1) facilitative glucose transporter 49–66% in preimplantation embryos. Glucose uptake is reduced and apoptosis is activated. We hypothesized that the reduction of embryonic GLUT1 may play a key role in the malformations...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Heilig, Charles W., Saunders, Thomas, Brosius, Frank C., Moley, Kelle, Heilig, Kathleen, Baggs, Raymond, Guo, LiRong, Conner, David
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307616/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14673082/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2536196100
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