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Muscle-Specific F-Box Only Proteins Facilitate BK Channel β(1) Subunit Down-Regulation in Vascular Smooth Muscle Cells of Diabetes Mellitus
RATIONALE: Activity of the large conductance Ca(2+)-activated K(+) (BK) channels is profoundly modulated by its β(1) subunit (BK-β(1)). However, BK-β(1) expression is down-regulated in diabetic vessels. The ubiquitin-proteasome-system (UPS) is a major mechanism of intracellular protein degradation....
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076051/ https://ncbi.nlm.nih.gov/pubmed/20966391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.228361 |
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