Regulation of Coronary Arterial BK Channels by Caveolae-Mediated Angiotensin II Signaling in Diabetes Mellitus

RATIONALE: The large conductance Ca(2+)-activated K(+) (BK) channel, a key determinant of vascular tone, is regulated by angiotensin II (Ang II) type 1 receptor (AT(1)R) signaling. Upregulation of Ang II functions and downregulation of BK channel activities have been reported in diabetic vessels. Ho...

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Bibliographic Details
Main Authors: Lu, Tong, Zhang, Dai-Min, Wang, Xiao-Li, He, Tongrong, Wang, Ru-Xing, Chai, Qiang, Katusic, Zvonimir S., Lee, Hon-Chi
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927991/
https://ncbi.nlm.nih.gov/pubmed/20167931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.209767
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