Deletion of the Dual Specific Phosphatase-4 (DUSP-4) Gene Reveals an Essential Non-redundant Role for MAP Kinase Phosphatase-2 (MKP-2) in Proliferation and Cell Survival

Mitogen-activated protein kinase phosphatase-2 (MKP-2) is a type 1 nuclear dual specific phosphatase (DUSP) implicated in a number of cancers. We examined the role of MKP-2 in the regulation of MAP kinase phosphorylation, cell proliferation, and survival responses in mouse embryonic fibroblasts (MEF...

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Autors principals: Lawan, Ahmed, Al-Harthi, Sameer, Cadalbert, Laurence, McCluskey, Anthony G., Shweash, Muhannad, Grassia, Gianluca, Grant, Anne, Boyd, Marie, Currie, Susan, Plevin, Robin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075640/
https://ncbi.nlm.nih.gov/pubmed/21317287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.181370
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