The Dual-Specificity Protein Phosphatase DUSP9/MKP-4 Is Essential for Placental Function but Is Not Required for Normal Embryonic Development

To elucidate the physiological role(s) of DUSP9 (dual-specificity phosphatase 9), also known as MKP-4 (mitogen-activated protein kinase [MAPK] phosphatase 4), the gene was deleted in mice. Crossing male chimeras with wild-type females resulted in heterozygous (DUSP9(+/−)) females. However, when thes...

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Detalhes bibliográficos
Main Authors: Christie, Graham R., Williams, David J., MacIsaac, Fiona, Dickinson, Robin J., Rosewell, Ian, Keyse, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1234323/
https://ncbi.nlm.nih.gov/pubmed/16135819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.18.8323-8333.2005
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