DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212

Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major mental illnesses, regulates multiple aspects of embryonic and adult neurogenesis. Here we show that DISC1 suppression in newborn neurons of the adult hippocampus leads to over-activated signaling of AKT, another schizophrenia susc...

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Detalhes bibliográficos
Main Authors: Kim, Ju Young, Duan, Xin, Liu, Cindy Y., Jang, Mi-Hyeon, Guo, Junjie U., Pow-anpongkul, Nattapol, Kang, Eunchai, Song, Hongjun, Ming, Guo-li
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075620/
https://ncbi.nlm.nih.gov/pubmed/19778506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.08.008
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