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Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
The p53 transcription factor is activated by various types of cell stress or DNA damage, and induces the expression of genes that control cell growth and inhibit tumor formation. Analysis of mice that express mutant forms of p53 suggest that inappropriate p53 activation can alter tissue homeostasis...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075331/ https://ncbi.nlm.nih.gov/pubmed/21334322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2011.02.007 |
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