Dysfunction of the MDM2/p53 axis is linked to premature aging

The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin ligase MDM2 via an autoregulatory feedback loop. In addition to its well-established role in tumorigenesis, p53 has also been associated with aging in mice. Several mouse models...

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Udgivet i:J Clin Invest
Main Authors: Lessel, Davor, Wu, Danyi, Trujillo, Carlos, Ramezani, Thomas, Lessel, Ivana, Alwasiyah, Mohammad K., Saha, Bidisha, Hisama, Fuki M., Rading, Katrin, Goebel, Ingrid, Schütz, Petra, Speit, Günter, Högel, Josef, Thiele, Holger, Nürnberg, Gudrun, Nürnberg, Peter, Hammerschmidt, Matthias, Zhu, Yan, Tong, David R., Katz, Chen, Martin, George M., Oshima, Junko, Prives, Carol, Kubisch, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617664/
https://ncbi.nlm.nih.gov/pubmed/28846075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92171
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