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Dysfunction of the MDM2/p53 axis is linked to premature aging
The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin ligase MDM2 via an autoregulatory feedback loop. In addition to its well-established role in tumorigenesis, p53 has also been associated with aging in mice. Several mouse models...
Zapisane w:
| Wydane w: | J Clin Invest |
|---|---|
| Główni autorzy: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Clinical Investigation
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617664/ https://ncbi.nlm.nih.gov/pubmed/28846075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92171 |
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