Dysfunction of the MDM2/p53 axis is linked to premature aging

The tumor suppressor p53, a master regulator of the cellular response to stress, is tightly regulated by the E3 ubiquitin ligase MDM2 via an autoregulatory feedback loop. In addition to its well-established role in tumorigenesis, p53 has also been associated with aging in mice. Several mouse models...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Lessel, Davor, Wu, Danyi, Trujillo, Carlos, Ramezani, Thomas, Lessel, Ivana, Alwasiyah, Mohammad K., Saha, Bidisha, Hisama, Fuki M., Rading, Katrin, Goebel, Ingrid, Schütz, Petra, Speit, Günter, Högel, Josef, Thiele, Holger, Nürnberg, Gudrun, Nürnberg, Peter, Hammerschmidt, Matthias, Zhu, Yan, Tong, David R., Katz, Chen, Martin, George M., Oshima, Junko, Prives, Carol, Kubisch, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617664/
https://ncbi.nlm.nih.gov/pubmed/28846075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92171
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