Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists

Chemokine receptors are critical regulators of cell migration in the context of immune surveillance, inflammation and development. The G protein-coupled chemokine receptor, CXCR4, is specifically implicated in cancer metastasis and HIV-1 infection. Here we report five independent crystal structures...

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Autors principals: Wu, Beili, Chien, Ellen Y.T., Mol, Clifford D., Fenalti, Gustavo, Liu, Wei, Katritch, Vsevolod, Abagyan, Ruben, Brooun, Alexei, Wells, Peter, Bi, F. Christopher, Hamel, Damon J., Kuhn, Peter, Handel, Tracy M., Cherezov, Vadim, Stevens, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074590/
https://ncbi.nlm.nih.gov/pubmed/20929726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1194396
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